B-NDG hFcRn mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen,drug development,antibody discovery

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動物・細胞モデル

Immunodeficient Mice/Rats

Immunodeficient (B-NDG) Mice

Text

B-NDG hFcRn mice

Strain Name

NOD.CB17-Prkdc^scidIl2rg^tm1BcgenFcgrt^{tm1(FCGRT)Bcgen}/Bcgen

Common Name

B-NDG hFcRn mice

Background

B-NDG

Catalog number

111922

Related Genes

FCGRT (Fc fragment of IgG receptor and transporter)

Protein expression analysis

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Strain specific analysis of FcRn expression in B-NDG mice and B-NDG hFcRn mice by western blot. Liver, kidney and spleen were collected from B-NDG mice (+/+) and homozygous B-NDG hFcRn mice (H/H) and analyzed by western blot with species-specific anti-FcRn antibody. Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H) but not in B-NDG mice (+/+).

Serum half-life of antibody drug in B-NDG hFcRn mice

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Pharmacokinetics of YERVOY-analog (isotype: human IgG1) in B-NDG hFcRn mice.

B-NDG mice and B-NDG hFcRn mice were intravenously injected with YERVOY (in house), the isotype of YERVOY (in house) is human IgG1, and serum was collected for pharmacokinetic (PK) analysis (n=3). A, The PK curve. B, The PK parameters. Data are shown in mean ± SEM.